|17||@Buccaneers||W 28 - 22||1||1|
|16||Jaguars||W 24 - 12||1||1|
|15||@49ers||W 29 - 22||1||1|
|14||Panthers||W 40 - 20||1||1|
|13||Saints||L 18 - 26||1||1|
|12||Buccaneers||L 22 - 35||1||1|
|11||@Panthers||W 29 - 3||1||1|
|10||@Saints||W 26 - 9||1||1|
|8||Seahawks||L 20 - 27||1||1|
|7||Rams||L 10 - 37||1||1|
|6||@Cardinals||L 33 - 34||1||1|
|5||@Texans||L 32 - 53||1||1|
|4||Titans||L 10 - 24||1||1|
|3||@Colts||L 24 - 27||1||1|
|2||Eagles||W 24 - 20||1||1|
|1||@Vikings||L 12 - 28||1||1|
- Started in all 16 games at center.
- A six-time Pro Bowler (2018, 2017, 2016, 2015, 2013, 2010), has started all 165 games in which he has played.
- One of three centers in Browns history to earn multiple Pro Bowl honors.
- Started all 16 games at center in 2018, blocking for an offense that averaged 389.1 yards and 6.16 yards per play, the sixth-best mark in the NFL.
- Named to the Pro Bowl (2018) for the fourth-straight season - third time as a Falcon.
- In 2017, blocked for an offense that averaged 364.8 yards and 5.93 yards per play, the third-best mark in the NFL.
- Started at center and blocked for an offense that totaled 322 yards, including 124 on the ground, in a 26-13 Wild-Card win over the Los Angeles Ram. Named to the Pro Bowl for the third-straight season - second time as a Falcon.
- Started all 16 games at center, blocking for an offense that set a franchise record with 540 points and averaged 415.8 yards per game in 2016. Earned his fourth career Pro Bowl selection in his first season with the Falcons after anchoring the offensive line for the NFL's top scoring unit.
- Started at center and blocked for an offense that set a franchise record with 571 total yards against Carolina (10/2/16). Protected QB Matt Ryan as he became the 19th player in NFL history to throw for 500+ yards in a single game.
- In 2015, Mack returned from injury to play in all 16 games and was selected to his third career Pro Bowl. Played every offensive snap (4,998 consecutive) through his first 80 career games, and was one of only four NFL offensive linemen to play every offensive snap for his team since at least 2009.Played and started in five games during the 2014 season in Cleveland before going down with an injury. During those five games, the offense averaged 26.8 points per game, 383.2 total yards per game, 146.4 rushing yards per game, and 4.4 yards per carry.
- In 2013, earned his second career Pro Bowl selection and was named a second-team AP All-Pro. Started all 16 games at center, playing all 1,106 offensive snaps.
- Was voted a first-alternate to the AFC Pro Bowl squad after starting all 16 games at center in 2012. Part of an offensive line that helped Trent Richardson set Browns rookie records in rushing yards (950), rushing TDs (11) and total scrimmage yards (1,317).
- Started all 16 games at center in 2011, and did not miss an offensive snap, despite undergoing an appendectomy in October. In 2010, Mack anchored an offensive line that helped Peyton Hillis rush for 1,177 yards and 11 touchdowns. Earned his first career Pro Bowl selection and was named to Sports Illustrated's All-Pro team.
- During his rookie season in 2009, Mack became the fifth rookie to start all 16 games at center and helped his team-record four consecutive games with more than 160 rushing yards.
- Was named to the Pro Football Weekly/Professional Football Writers of America All-Rookie team and selected to USA Today's All-Joe team. One of four rookie offensive linemen to start all 16 games in 2009, along with Buffalo's Andy Levitre (LG), Seattle's Max Unger (13 at RG, 3 at C) and Baltimore's Michael Oher (12 at RT, 4 at LT). Became just the fifth NFL rookie to start all 16 games at C since 1998, joining Damien Woody (New England, 1999), Alex Stepanovich (Arizona, 2004), Nick Mangold (Jets, 2006) and Samson Satele (Miami, 2007).